iKinase

http://appshopper.com/medical/ikinase

RDEA-119

This PDB entry confirms the structure.

as always, being 18 months behind the times put you 6 months ahead of the curve.

p38: Not dead?

Well.. maybe this compound will kill it: Polymorphic Forms / WO/2009/098612 & its from Pfizer no less –

Part Axitinib, part Birb, Part SGX… All MW: 700

Thanks for the email PN.

AT-131418

Astex has released data about their AKT program, including a PDB, but I have omitted that they appear to have dropped the strutcture of their candidate in WO/2008/110846

Thanks, Ed.

BMS-817378

A comments to BMS-777607 suggest that this structure is the backup:

WO/2009/094427

ENMD-2076

Its a salt form of ENMD-981693…

AZ’s got PI3K

WO/2009/093972 reminds you of…

Pi3k @ Bayer

This one hones in on the sulphonamides: (from the former site in CT)

WO/2009/091550; They stuck morpholines out there previously: WO/2008/070150

Biogen Nominated…

… A RAF candidate & Sunesis got a milestone,

In August 2004 the companies entered into a collaboration to discover and develop small molecule cancer therapeutics targeting kinases, a family of cell signaling enzymes that play a major role in the progression of cancer. The research term of this collaboration ended in June of 2008. Sunesis retains an option to participate in the co-development and co-promotion of the Raf kinase inhibitor resulting from this collaboration.

Likely derived from WO/2009/006389 &  WO/2009/006404

What do…

…the Bee Gee’s and R406 have in common?

R-788 (a prodrug of R-406) has shown promise in a Ph2b trial. Partner Plz?

still no BMCL